Association between the HLA-G*0105N polymorphism and recurrent abortion in women
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
In human pregnancies HLA-G (Human leukocyte antigens G) is supposed that play a main role in implantation. It is expressed on trophoblast cells that invades during pregnancy to the uterus decidua and is introduced to induce maternal tolerance immunologically against the fetus.
Objective
The aim of this study was to find association between the HLA-G*0105N polymorphism and recurrent abortion in women.
Methods
This case-control study was conducted on two groups of 108 women with history recurrent abortion (RSA) as a case group or without history RSA as a control group in Cellular and Molecular Research Center, Qazvin University of Medical Sciences in 2015. The frequency of null allele of HLA-G*0105N was studied in two groups by PCR -RFLP method. Allele and genotype frequencies of two group were compared using Hardy-Weinberg equilibrium and Chi-square test.
Findings: In case group, 54 (50%) and 17 (15.7%) were heterozygous and homozygous respectively for HLA-G*0105N polymorphism. In control group, only 9 (8%) was homozygous for HLA-G*0105N polymorphism. But there was no significant difference between case and control on HLA-G*0105N allele with RSA (P=0.1004).
Conclusion
As the results, there was no significant association between HLA-G*0105N poly morphism and RSA. Thus, it seems that this HLA-G*0105N polymorphism may effective in relation with other genes or polymorphisms in RSA.
Language:
Persian
Published:
Journal of Inflammatory Diseases, Volume:21 Issue: 6, 2018
Pages:
30 to 37
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