The Effect of Saffron Supplementation on Serum Matrix Metallopeptidase 9 (MMP9) and Ejection Fraction Following High Intensity Aerobic Training in Patients with Coronary Artery Bypass Graft Surgery

The purpose of this study was to evaluate the effect of saffron supplementation on matrix metallopeptidase 9 (MMP9) and ejection fraction following high intensity exercise in patients with coronary artery bypass graft (CABG).
In this practical quasi-experimental study, about one month after their surgery, 30 patients were selected and randomly assigned to 2 groups. Exercise group in each session did two 10-minute sessions of intense periodic exercises and 15 seconds of activity with 100% peak power, 15 seconds of passive rest, and 4 minutes of rest between the two 10-minute sessions; the supplementation group more than exercises received daily 300 mg saffron supplement after lunch. ANOVA and Bonferron's post-hoc test were used to determine the difference and the location of the difference, respectively. All statistical analysis was done at the significant level of P Findings: The implementation of periodic exercises did not significantly increase the amount of matrix metallopeptidase 9 factor. Significant increase was seen in ejection fraction among exercise and supplementation groups compared to the control group (P In this study, the results showed that periodic exercise did not significantly increase the level of matrix metallopeptidase 9. The increase was in the effective ejection fraction, which in improved the angiogenesis and blood discharges in patients after the coronary artery bypass graft surgery.