Mean Urinary Cytokine MCP-1 in Children with Urinary Tract Obstruction and Healthy Children
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background And Objectives
Hydronephrosis is defined as varying degrees of dilatation in renal pelvis and calyxes, which leads to renal parenchymal atrophy together with obstruction of urinary flow. The present study was conducted to compare levels of urinary cytokine MCP-1 in children with urinary obstruction and healthy children attending Ali-Asghar hospital of the city of Zahedan.
Methods
The present case-control study recruited 20 children with obstructive hydronephrosis, 20 children with non-obstructive hydronephrosis, and 30 healthy children as the control group that matched in terms of gender and age and were selected by the convenience sampling method. Urine samples were taken from these children, and urinary creatinine and MCP-1 levels were measured. Data were analyzed with the SPSS-21 software using analysis of variance (ANOVA), Kruskal-Wallis, and Mann-Whitney tests.
Results
Mean MCP-1 level was 542.56 ng/L in the obstructive hydronephrosis group, 424.7 ng/L in the non-obstructive hydronephrosis, and 335.97 ng/L in the control group. Mean MCP-1 to creatinine ratio was 58.94 in the obstructive hydronephrosis group, 39.58 in non-obstructive hydronephrosis, and 33.1 in the control group. Mean MCP-1 and MCP-1 to creatinine ratio was significantly higher in the obstructive hydronephrosis group compared with non-obstructive hydronephrosis and control groups (P
Conclusions
The present study results showed that MCP-1 could be a marker for renal tubular injury in patients with obstructive hydronephrosis.
Language:
English
Published:
Nephro-Urology Monthly, Volume:10 Issue: 2, Mar 2018
Page:
7
magiran.com/p1822020  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!