Comparative Prevalence of blaCTX-M-15 Gene with Virulence Genes and Serotypes in Klebsiella pneumoniae
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
A newly emerged hypervirulent strain of Klebsiella pneumoniae has caused great concern globally; however, its molecular characteristics have been rarely reported in Iran.
Objectives
The goal of this study was to detect the virulence determinants and serotypes of K. pneumoniae and to evaluate the association among selected virulence traits and blaCTX-M-15 gene in southeastern Iran.
Methods
One hundred and three non-duplicate K. pneumoniae strains were isolated from clinical samples. The isolates were identified by standard bacteriological tests. Confirmed isolates were examined to detect a selection of virulence genes (wabG, rmpA and iucB) and serotypes (K1, K2, K5 and K20) by PCR. The isolates were studied foe the presence of beta-lactamase (blaCTX-M-15) gene. SPSS software (version 19.0) was used for data analysis.
Results
Among the 103 K. pneumoniae isolates, 61 (59.2%) isolates were positive for wabG, 4 (3.9%) for iucB and 3 (2.9%) for rmpA genes. The presence of K20 in 3.9% (4/103) of the isolates represented the most prevalent. Only 3 (2.9%) isolates possessed the K1 serotype, while K2 and K5 serotypes were not detected in any isolate. The blaCTX-M-15 gene was detected in 47 (45.6%) isolates. blaCTX-M-15-positive isolates showed a higher prevalence of wabG among the studied isolates (P
Conclusions
Our data indicate a correlation between presence of virulence gene and blaCTX-M-15 in K. pneumonia isolates. Further research should be undertaken to unravel aspects of both virulence factors and antibiotic resistance which may probably contribute to managing future spread of infectious diseases.
Language:
English
Published:
Jundishapur Journal of Microbiology, Volume:11 Issue: 4, Apr 2018
Page:
6
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