Anxiolytic-Like Effect of Methanol Leaf Extract of Laggera aurita Linn. F. (Asteraceae) in Mice

Laggera aurita belongs to the Asteraceae family; it is an annual herb found growing as weeds in Sub-Saharan Africa, including Nigeria. In Nigeria, Laggera aurita is used as a remedy for paediatric malaria and in the management of epilepsy. Previous studies on extracts of this plant suggested its anticonvulsant activity via GABA-mediated neurotransmission. Therefore, this study aimed at evaluating anxiolytic-like effect of the plant extract.
Anxiolytic potential of the methanol leaf extract of Laggera aurita was evaluated using staircase, elevated plus maze, hole board, open field, beam walking assay, and diazepam-induced sleep tests.
The extract significantly (P The results of this study revealed that the leaf extract of Laggera aurita possesses anxiolytic-like properties.