The Effect of Eight Weeks Aerobic Training with Royal Jelly Consumption on Some Cardiovascular Biomarkers During Chronic High Blood Pressure Induced By L-NAME in Male Rats

Hypertansion is one of the most common causes of cardiovascular disease that it can be controlled Using non-pharmacological strategies such as exercise and antioxidant supplements. The aim of this study was to investigate the effect of aerobic training with Royal Jelly (RJ) supplement consumption on angiotensin-converting enzyme inhibitor (ACE-I), nitric oxide (NO) and VEGF of heart tissue in rats with hypertension. 42 male mice were randomly divided into six groups: control, sham, L-NAME, L-NAME , L-NAME exercise, L-NAME RJ exercise. All groups were injected L-NAME solution at a dose of 10 mg/kg for 8 weeks and 6 days per week in sub peritoneum, except the control and sham groups. The exercise protocol in training groups was treadmill exercise with speed of 15 to 22 meters per minute for 25 to 64 minutes, 5 times in per week for 8 weeks. Supplement groups received RJ supplements at a dose of 100 mg/kg for 8 weeks and 5 times in per week through gavage. Measurement of the biomarkers was performed using the desired kit and ELISA method. Results show that plasma levels of NO and ACE-I increased in the combination group (exercise RJ L-NAME) compared with L-name group. Also, the VEGF levels of heart tissue increased in exercise and combination group compared with L-NAME group P