The healing effect of Teucriumpolium L. on acetic acid-induced colitis in male Rat

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, a chronic condition of the intestine with unknown etiology involving different agents immune, genetic and environment. Today, many of herbal and synthetic compounds are being used as anti-inflammatory products around the world. The aim of this study was to investigate the anti-inflammatory effect of aquatic extraction of Teucrium polium L. plant.

In this experimental study, a total of 135 male rats, weighing 200±20 g and 10 to 12 weeks old, were randomly divided into nine equal groups: healthy control group were given normal saline without ulcerative colitis (UC) induction, negative control group which UC was induced by 3% acetic acid with no treatment, basal gel group which were received basal gel via enema after UC induction, two groups as positive controls were taken Asacol (10 mg/kg/day) and Mesalamine (10 mg/kg/day) transrectally and orally, respectively. Also, oral form of aqueous extraction 50 and 100 mg/kg/day and enema form (gel 10% and 20%) of Teucrium polium L. were given. At the end of study, MDA measurement as antioxidant index and histopathological evaluation of colon tissue was performed. The collected data were analysed using one-way ANOVA and Mann–Whitney U test.

the results showed that groups were received enema gels 10% and 20% compared with other groups significantly repaired damaged tissue of colon at the microscopic level and caused reduction in MDA level (p­

Teucrium polium L. has remarkable effects on healing processing of induced colitis in rat. According to anti-inflammation and anti-microbial properties of Teucrium polium L., it can be mentioned that this plant is effective in healing of intestinal ulcers. Also, antioxidant materials of Teucrium polium L. accelerate healing processing.