Antibiotic susceptibility patterns and ESBL of Escherichia coli isolated from hospitalized patients in Kermanshah, western Iran

Production of Extended-spectrum ß-lactamases (ESBLs) is major cause of resistance to β-lactam antibiotics in Escherichia coli (E. coli).In this study the antibiotic susceptibility pattern and the prevalence of ESBL producing E. coli isolates were studied in a teaching hospital in Kermanshah, west of Iran.
E.coli isolates identified using microbiological and biochemical standard tests. Antibiotic susceptibility testing and detection of ESBL producing E.coli isolates were done according to Clinical and Laboratory Standards Institute (CLSI) criteria.
The most frequent isolation source of E.coli clinical isolates was urine (94.1%). Most of isolates were resistant against ampicillin (88.2%). Imipenem and amikacin were the most active antibiotic having 81.2% and 78.8% activity, respectively. Results of antimicrobial susceptibility showed that 57.6% of isolate were multidrug-resistant (MDR). Results of Combined Disk Test (CDT) showed that 56.5% of isolates were ESBL positive and among MDR isolates 79.6% of were ESBL producer. There was a statistical significantly difference in ESBL MDR pattern between ESBL producer and non-producer ESBL E.coli isolates (p Results of this study showed the most of isolates were MDR and poses problems for therapeutics. Prevention and control of antibiotics resistance requires efforts at increasing surveillance and infection control and also limitation of unnecessary antibiotic use.