The Diagnostic Value of Serum CEA, CA-125, and ROMA Index in Low-Grade Serous Ovarian Cancer
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Ovarian cancer (OC) has been reported as one of the three most prevalent malignant tumors in women. It has an onset of a difficult early diagnosis. The early detection of diseases has a vital role in survival rate of patients; the ovarian malignant tumor is no exception. The currently used tumor markers for differentiating low and high-risk levels of this disease are cancer (carbohydrate) antigen 125 (CA 125) as well as the risk of ovarian malignancy algorithm (ROMA). Carcinoembryonic antigen (CEA) is fetal glycoprotein synthesized in fetal tissues and in some carcinomas.Objectives
In this study, we investigated ROMA, CA-125, and CEA to evaluate the efficacy of these markers as predictors of peritoneal dissemination in early diagnosis of low-grade serous ovarian cancer.Methods
In this experimental study, CA-125, CEA, ROMA were determined in 10 patients with early-stage serous ovarian cancer and in 10 patients with benign tumors. Values and a cut-off level of CA-125, CEA, and ROMA were defined as positive when the values were as expected for ovarian cancer (CA-125 > 35 U/mL, CEA Results
In our patients, the serum level of CA-125, CEA, and ROMA was higher in patients who were at their early stage of serous ovarian cancer than those with benign tumors.Conclusions
In this study, the difference between CA-125, ROMA, CEA levels in healthy and malignant cancerous patients was statistically significant, which is encouraging. The finding indicates that combined results of serum CA125, ROMA, and CEA can be considered as a promising biomarker for early stage detection of serous ovarian cancer. Keywords:
CEA , CA , 125 , Ovarian Neoplasms
Language:
English
Published:
International Journal of Cancer Management, Volume:11 Issue: 5, May 2018
Page:
1
magiran.com/p1841164
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!