Hypoglycemic Interactional Effects of Coriandrum Sativum Extract and Endurance Training in Diabetic Rats

Diabetes is a chronic disorder which is recognized by hyperglycemia and Different methods such as exercise, drugs and herbal medicines are used to treat and manage diabetes. The purpose of this study was to investigate hypoglycemic interactive effects of Coriander extract and endurance training in diabetic rats.
Thirty-two diabetic rats were selected and divided into 4 groups ; (1) coriander extract( n =8), (2) endurance training( n =8),(3) coriander extract with endurance training( n =8),and (4) control ( n =8). Groups 1 and 3 received 100 mg / kg of coriander daily for 4 weeks, Also, groups 2 and 3 for 4 weeks, 5 sessions per week and 60 minutes each session ran on treadmill. To analyze the findings, Shapirovailk test, dependent t-test, one way ANOVA and Tukey post hoc test were used (p ≤ 0.05).
Four weeks of Coriander extract intake, endurance training and coriander extract with endurance training significantly decreased fasting glucose, insulin resistance and HbA1c in diabetic rats (p=0.001); Consumption of coriander extract with endurance training compared to coriander extract (p = 0.001) and endurance training (p=0.03) had a greater effect on the reduction of fasting glucose in diabetic rats. Also, coriander extract with endurance training compared to coriander extract had a greater effect on reducing the HbA1c in diabetic rats (p=0.02).
Due to reduction of glycemic indexes, It seems that coriander extract with endurance training used for four weeks has hypoglycemic interactions in diabetic rats.