Relationship of CD147 kidney expression with various pathologic lesions, biochemical and demographic data in patients with classes III and IV of lupus nephritis
Author(s):
Article Type:
Research/Original Article (بدون رتبه معتبر)
Abstract:
Background
Systemic lupus erythematosus (SLE) is a chronic inflammatory disorder that affects the kidney in around 50% of patientsObjectives
The aim of this study was to assess CD147 expression with various pathologic lesions, biochemical and demographic data in patients with classes III and IV lupus nephritis.Patients and
Methods
These patients with lupus nephritis classes II and IV by renal biopsy and pathology were enrolled in this study. The strength of CD147 staining on tubules, Bowmans capsules, vessels and tuft of glomeruli was expressed as proportion of involvement.Results
In this study, 23 renal biopsies for lupus nephritis of classes III and IV (documented by immunofluorescence and light microscopic studies) were included. No significant difference of CD147 staining between classes was detected (P>0.05). In addition, proportion of proteinuria was not related to CD147 staining in tubules, Bowmans capsules, vessels and tuft of glomeruli in classes III and IV lupus nephritis (P>0.05). There was no significant association of CD147 staining in tubules, Bowmans capsules and vessels with serum creatinine (P>0.05). However, an association between CD147 staining in tuft of glomeruli with serum creatinine was detected (r=0.623, P=0.002). None of chronicity or activity percent of glomerular involvement in two classes of III or IV had a significant association with CD147 staining (P>0.05).Conclusions
The significant association between CD147 staining in glomeruli with serum creatinine in lupus nephritis of classes III and IV revealed that inflammation at this area may have prognostic implication.Keywords:
Language:
English
Published:
Journal of nephropathology, Volume:7 Issue: 3, Jul 2018
Pages:
101 to 105
magiran.com/p1851045
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!