Antifungal and Synergistic Effects of Aqueous and Alcoholic Extracts of Green Tea with Itraconazole and Voriconazole on Aspergillus Species

Aims: In this study, the replacement of natural compounds such as green tea by chemical drugs like itraconazole and voriconazole was studied.
In this study, the effects of the aqueous and methanol extracts of green tea and the synergistic effects of these two extracts were studied along with two drugs of itraconazole and voriconazole against four strains of Aspergillus accordaing to microdilution method to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC).
Findings: Two strains of A.flavus ATCC39 and A.terreus ATCC274 are sensitive to itraconazole while two other strains were resistant. All four tested strains were resistant to voriconazole. The aqueous and methanol extracts of green tea did not show antifungal effect but synergistic effects of aqueous extract of green tea and itraconazole were worthwhile against A.niger ATCC9142 and A.fumigatus ATCC278. Also, the combined methanol extracts of green tea and itraconazole against A.niger ATCC9142 and the combined aqueous extracts of green tea and voriconazole against A.flavus ATCC 39 and A.fumigatus ATCC278 were reported valuable.
The results of this study showed that there is a valuable synergistic effect between the tested antifungal drugs and the extracts.