Detection and Localization of HCA2 Receptors in Urinary System of Male Rats with Immunohistochemical Method
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background And Aims
HCA2 receptors have attracted much interest due to their role as the target of important hypolipidemic agent, niacin. In this study, the presence of HCA2 receptors as well as cell types that express them has been evaluated in different parts of male rat's urinary system including kidney, ureter, urinary bladder and urethra (in penis).
Methods
In this experimental study, six adult male Wistar rats were used. Histological slides were made from above mentioned parts and were evaluated by immunohistochemical method.
Results
In kidney, capillary epithelium showed a high reactivity while proximal epithelial cells were stained moderately. The epithelial cells of loop of Henle, distal and collective tubules as well as glomerular cells showed weak staining. In urinary bladder, transitional epithelium and capillary endothelium showed weak staining, while smooth muscle had no reactivity. In penile tissue, urethral epithelium and smooth muscle cells were weakly positive while capillary endothelial cells showed moderate reactivity.
Conclusion
This study shows that HCA2 receptors are present in different parts of male rat's urinary tract. Distribution of these receptors is dependent to cell type and location in the urinary tract. The findings pave the road for future studies on possible role of these receptors in urinary system.
Language:
Persian
Published:
Journal of Shahrekord University of Medical Sciences, Volume:20 Issue: 3, 2018
Pages:
43 to 49
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