Effect of High Intensity Interval Training on miR-1, miR133-a Gene Expression in Rats with Myocardial Infarction

The aim of this study was to investigate the effect of intensive interval training on miR-1, miR133-a gene expression in rats with myocardial infraction. For this purpose, 12 Wistar male rats with 10 weeks old and average weight 250-300gr that infected to Myocardial infarction and they were designed in to two groups of experimental (60 minutes of interval running on treadmills that each interval is 4 minutes of running with the 85-90 percent of Vo2max and 2 minutes of active rest at 50-60 percent of Vo2max for four days in a week and 6 weeks) and control group (without any training). Genes expression was investigated by the PCR technique and data were analyzed by the SPSS 18 with T test (α≤0.05). The findings of present study showed that the levels of miR-1 in high intensity interval training (4.33mg.ml-1) significantly much more than the control group (3.541mg.ml-1)(P=0.012) and the amount of miR-133a in high intensity interval training group (4.876 mg.ml-1) was also much more than control group (1.01mg.ml-1)(P≤0.001) . in general, 6 weeks of high intensity interval training with intensity of 50-60 percent of Vo2max leads to increased expression of miR-1 and miR-133a in male Vistar rats with MI.