Hindlimb Unloading Effects on β-Endorphin Receptor in Rats

Space is a harsh environment that affects the body in many ways. Humans venturing into the environment of space can have negative effects on the body.
This study focused on the effects of simulated microgravity on β-endorphin receptor concentration.
Rats (n = 16) were divided in two groups (n = 8/group), freely moving (control group) and hindlimb unloading. A rat-tail suspension model was used in experiment groups for 14 days to explore the effect of simulated microgravity on the β-endorphin receptor concentration in the hippocampus, brain stem, and prefrontal cortex.
The results showed that the concentration of β-endorphin receptor in the brain stem and prefrontal cortex, but not in hippocampus, was significantly higher in hindlimb unloading rats than controls.
It is possible that simulated microgravity may increase the β-endorphin receptor expression in the prefrontal cortex and brain stem in the rat.