Cytotoxic effect of the extract of seaweed Sargassum glaucescens against breast (MCF-7) and colorectal (HT-29) cancer cell lines
Message:
Abstract:
Background
Seaweed is one of the natural resources with a wide range of secondary metabolites, which has cytotoxic properties. The present study aimed to investigate the cytotoxic effect of seaweed Sargassum glaucescens collected from Chabahar seashores against colorectal and breast cancer cells.
Materials And Methods
The cytotoxicity of methanol, chloroform, ethyl-acetate and hexane extracts of the seaweed at different concentrations (125, 250, 500 and 1000 μg/ml) against cancer cells of MCF-7 and HT-29 was evaluated by MTT and trypan blue methods. The DNA fragmentation of cells was also investigated by the electrophoresis method.
Results
The percentage of live cells was decreased by increasing the concentration of the extracts. The concentration of 1000 μg/ml of methanol extract showed the highest effect compared to the control and also lower concentrations of the extract (P
Conclusion
The cytotoxic effect of the seaweed extract can be the beginning of further studies to achieve cancer treatment. Also, after pre-clinical and clinical studies, these extracts can be used in the food and pharmaceutical industries.
Article Type:
Research/Original Article
Language:
Persian
Published:
Pages:
292 - 301
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