Association Between 50 bp Insertion/Deletion Polymorphism in Promoter of the Superoxide Dismutase-1 and Temperament

Mizaj, one of the basic concept of Iranian Traditional Medicine (ITM), plays an important role in maintaining the healthy state of an individual as well as diagnosis and treatment of diseases. Despite its effectiveness, the mechanisms of mizaj dependence treatment in practical ITM has not been steel well understood. This study was aimed to evaluate any association between the mizaj and superoxide dismutase-1 (SOD1) polymorphism. The study was carried out on individuals healthy for blood donation. All participants were from Fars province, southern Iran. To determine the Participants’ temperaments a self-reported mizaj identification scale was used. Two hundred eighty males with equilibrium or any of four simple mizajs (Warm, Cold, Moist, and Dry) were included in the study. The SOD1 genotypes were determined using a polymerase chain reaction (PCR)-based method. Multinomial logistic regression was used to calculate ORs and 95% CI for the association of temperament with SOD1 polymorphism. No any association between the Ins/Del polymorphism of SOD1 and each of mizaj groups were found. The result of this study indicated that the temperament is not affected by the Ins/Del polymorphism of SOD1. Further research with larger samples and with other genes of antioxidant system is recommended.