The Effects of Resveratrol Supplementation on the Level of Adiponectin and Leptin in Type 2 Diabetic Patients

Resveratrol (RSV), one of the most effective natural polyphenolic compounds synthesized by plants, has antioxidant, anti-inflammation and anti-insulin-resistance properties. Some studies suggest that the mechanism of action of RSV is mainly mediated by the deacetylase Sirt1. However, other studies have shown that RSV plays its role through other metabolic routes such as its stimulatory effect on the secretion of adiponectin. Adiponectin is a hormone that plays an important role in the regulation of insu-lin sensitivity and energy homeostasis. In addition, RSV can control obesity by preventing the develop-ment of central leptin resistance. This study aimed to evaluate the effect of RSV on blood concentration of adiponectin and leptin in patients with type 2 diabetes.
This double-blind randomized clinical trial recruited 51 patients with type II diabetes from a previous study. Patients’ demographics and medical history were recorded in an inter-view. The intervention group received 500 mg RSV capsules twice a day for 45 days while the control group received identical placebo capsules. Blood pressure, weight, BMI, lipid profile, blood levels of adi-ponectin, leptin and liver function tests were measured at baseline. Data were analyzed using descriptive statistics and independent t-test in SPSS 18.
There were no differences in the concentration of adiponectin and leptin between the two groups. However, Mann-Whitney test revealed a difference in the concentration of leptin between intervention and control groups (p= 0.025). That is, the blood level of leptin was significantly more in the intervention group. The results of this study suggest that supplementation of 1 g per day of RSV for 45 days has no effect on the blood level of adiponectin and leptin in patients with type 2 diabetes