An overview on VEGFR-1 and VEGFR-2 growth receptors of lung and their acute and chronic responses to exercise stress

The Lung is an organ with wide capillary network and bronchial tree with the highest expression of growth factors in its cells. There is physiological balance between antiangiogenic and proangiogenic factors expression in normal situation, but this balance would be destroyed because of various stressors like growth, injury, different diseases and exercise training. VEGFR-1 and VEGFR-2 are the most important angiogenic receptors in lung with important effects on structure and function of lung tissue via VEGF signaling. The Exercise training can affect the expression or activity of these receptors through various mechanisms and thereby change lung mitogenic structure and function. The available knowledge about the response and compatibility of these receptors in the lung to the various exercise trainings is not clear enough.