Simultaneous Study On the effects of jujube alcohol extract, Gallic acid, and endurance training on histopathology changes of the hippocampus in male rats which had been poisoned by anabolic steroids

Anabolic Steroid hormones are commonly misued by athletes in order to improve athletic performance. The aim of present research is the simultaneous study of the effect of jujube alcohol extract, Gallic acid and endurance training on histopathology changes of Hippocampus in male rats, which had been poisoned by anabolic steroids.
In this research, female wistar rats, weighing from 200-250g were selected randomly and divided into 10 groups as follows: Group 1- control, group 2 - instinct, group 3 - poisoned by Boldenon (5 mg/kg), group 4 - jujube Boldenon, group 5 - Gallic acid Boldenon, group 6 - Endurance Training Boldenon (5mil/gr), group 7 jujube plus endurance training, group 8 - Gallic acid plus endurance training, group 9 Boldenon (2 mg/kg), group 10 Boldenon 2mg plus endurance training. After 8 weeks of endurance training and receiving Boldenon weekly through muscular injection, tissue sampling was done on the rats and then a histopathology study was conducted.
The findings show that the structural changes of the hippocampus in all groups in comparison to the control group are significantly higher, but there was no inflammation in any group. Based on the results of present study, using Boldenon (high dosage – low dosage) causes structural changes in Hippocampus.
Discussion and based on the present research, it was found that structural changes of hippocampus tissue caused by poisoning by Boldenon in all groups was significantly more than in the control group. However, in no group, was enlargement seen. It was also shown that endurance jujube essence, and Gallic acid has some effects in decreasing neurological damage caused by receiving Boldenon and has synergistic effects.