Correlation between mean E/E? ratio with invasive measurement of left ventricular end-diastolic pressure

Left ventricular filling pressure (LVFP) determination is a key step in predicting prognosis and making an appropriate therapeutic strategy, especially in patients with heart failure. Left cardiac catheterization allows an accurate and direct evaluation of some hemodynamic variables that estimate LVFP. But, since this method is not completely free from complications, several different methods, especially echocardiographic, were used in order to non invasively evaluate LVFP. The aim of this study was to determine the accuracy of E/E’ ratio in non-invasive prediction of LVFP in patients with different EF.
In this study, LVEDP was measured in cardiac catheterization for 50 patients with sinus rhythm under left ventricular catheterization. Also, the mean E/E’ ratio (early diastolic mitral inflow velocity to annular velocity) was measured by Doppler echocardiography in all patients. At the end, the relationship between echocardiographic measurements and cardiac catheterization measuring LVEDP was evaluated.
The mean age of patients was 57.71 ± 11.72 years and 37 (61.7%) were male. The mean E/E’ ratio was 11.06 ± 4.17 cm/s and the mean LVEDP was 12.9 ± 3.96 mm Hg. The Pearson correlation between E/E' ratio and LVEDP was 0.717 (p 55%, and the weakest correlation in the EF=35-44.
The results of this study show that the evaluation of left ventricular filling pressure using a non-invasive calculation of E/E’ ratio in echocardiography has high accuracy and can replaced and used instead of invasive methods