Expression of Transforming Growth Factor Beta in Giant-cell Granuloma of Jaws and Giant-cell Tumor of Bone
Background And ObjectivesPeripheral and central giant-cell granulomas (PGCGs and CGCGs) and giant-cell tumor (GCT) of bone have similar histopathological features with different biological behavior. The aim of this study was to evaluate the expression of transforming growth factor beta (TGF-β) in these lesions by the help of immunohistochemistry.
Materials And MethodsIn this study, 15 PGCGs, 15 CGCGs, and 10 GCTs were evaluated. The TGF-β immunoreactivity was assessed in mononuclear cells (MC) and multinucleated giant cells (MGC) of the studied groups. Data analysis was performed using Kruskal-Wallis and Dunns tests.
ResultsThere was a significant difference between three studied groups regarding both MCs and MGCs. The highest mean of TGF-β immunostaining was observed in GCTs and the lowest in PGCGs. In pairwise comparison of the studied groups, a significant difference was observed between PGCGs and GCTs considering both MCs and MGCs. Additionally, a significant deference was reported only in MCs between CGCGs and GCTs.
ConclusionThe results may explain the different biological behavior and pathogenesis of these lesions despite the similarity of histopathologic features.
Journal of Mashhad Dental School, Volume:42 Issue:3, 2018
221 - 228
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