Serum - based microRNA biomarkers for major depression: MiR-16, miR-135a, and miR-1202

Depression is a common medical condition with a high prevalence leading to emotional abnormality. Despite some drawbacks, depression currently diagnosed using a combination of patient interviews and self?report questionnaires. Recently, there is emerging emphasis to establish biomarkers to diagnosis and clinical management of depression. Tis case–control study was designed to develop microRNA (miRNA)?based serum biomarker for depression.
In this study, 39 patients with depression and 36 healthy controls were enrolled. Serum miRNAs gene expression was measured using real?time polymerase chain reaction (PCR) analysis; fnally, the data represent as the 2–?Ct followed by further statistical analysis.
Te serum level of miR?16 was signifcantly (P Our fndings showed that these miRNA can be used as a biomarker of depression diagnosis. MiR?135a and miR?1202 exhibited better sensitivity and specifcity, respectively.