Pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensives

First?degree relatives (FDRs) of hypertensive (HT) are predisposed to hypertension (HTN) which accelerates cardiovascular aging. Same can be studied noninvasively by pulse wave analysis (PWA), encompassing central hemodynamics such as central blood pressure (cBP), cardiac output, and stroke work (SW) and vascular sti?ness parameters such as pulse wave velocity (PWV) and augmentation index at HR 75 (AIx@75). We studied PWA?derived cardiovascular parameters in FDRs of HT compared to controls.
We conducted a case–control study in 119 FDRs of HT and 119 matched controls. Oscillometric PWA was performed by Mobil?o?Graph (IEM, Germany) and cardiovascular parameters were compared. P Groups were comparable with gender, age, height, weight, body mass index, and physical activity. FDRs of HT had signifcantly higher brachial and cBPs, SW (101.41 ± 25.44 vs. 88.31 ± 20.25, P = 0.001), rate pressure product?119.40 ± 25.34 vs. 108.34 ± 18.17, P PWA reveals early cardiovascular aging in young FDRs of HTs. It clues to future cardiovascular disease including HTN itself, need for primary prevention, and further study for consolidation of these results.