The Effect of Methamphetamine Injection during Post-Lactation on the Ovaries of Adult Rats

Methamphetamine (MAMP) is a central nervous system stimulant, which its consumption has increased among young people. In this study, the effects of methamphetamine were investigated on ovarian tissue structure in immature rats.
In this experimental study, 40 immature female Wistar rats after lactation, were divided into four groups: control group that received normal saline and treatment groups that received methamphetamine at the doses of 1, 3, and 5mg/kg for 10 days intraperitoneally. After puberty, the rats were dissected and their ovary was removed. The histological sections were prepared from the ovary by hematoxylin eosin staining and examined morphologically. In the tissue sections, the number of primary follicles, growing follicles, graafian follicle, corpus luteum, and corpus albicans, were counted and compared by ANOVA between different groups.
There was no significant difference between mean weight of mice and ovary after puberty in the treatment groups compared to the control group. The mean number of primary follicles (at all doses) and growing follicles (at doses of 3 and 5mg/kg), were significantly decreased in a dose-dependent manner (p Methamphetamine may interfere with the secretion and activity of gonadotropin-releasing hormone (GnRH) by mimicking the body's naturally amphetamine compounds, and consequently causes disorder in the number and growth of follicles in the ovary the number and growth of follicles in the ovary, which may lead to absence of oocyte maturation and ovulation