Effect of alum on tongue wound healing in rats

Alum solution is used to treat skin ulcers, oral, gums, and to prevent dental caries. The aim of this study was to investigate the effect of alum on wound healing on the dorsal surface of rat tongue.

Twenty-four male Wistar rats were randomly divided into four groups (n = 6 in each group). With biopsy punched, wound to 4mm diameter and 1 mm depth created on rat’s tongue. Correspondingly, from the next day, the rats of the second, third and fourth groups received daily 0.1 ml of alum at concentrations of 7%, 10% and 14% on the wound's surface and control group received water. In the third, sixth and tenth days, the area of the wound surface was calculated using a gauge (1 / 10 mm).

In all groups, improvement in the wound surface area in different days was observed, and the wound healing process was significant in each group (P <0.05). However, alum was not effective in reducing the time of wound healing in comparison with the groups, and increasing the concentration of alum was no effect on wound healing.

Alum solution was not effective in wound healing on the dorsal surface of rats tongue in 7 - 14% concentrations. Therefore, it is suggested that the effects of other concentrations of alum, as well as repeated administration of the drug several times a day, and its effect on other diseases of oral wounds examined