The Effect of 6 Weeks Swimming and Consumption of Zingiber officinale Roscoe Extract on some Inflammatory and Anti-inflammatory Factors in Heart Tissue of Mice Induced by Breast Cancer

Background: Heart disease is one of the side effects of breast cancer. Physical activity and herbs are effective in reducing the inflammatory factors of the heart tissue.

The purpose of this study was to evaluate the effect of 6 weeks of swimming and ginger on some inflammatory factors of the heart tissue of mice induced by breast cancer.

60 female Balb C-female (6-8 weeks old) and (150-250 g weight) after induction of breast cancer (surgical technique) and familiarity with the environment were randomly divided into 6 groups: healthy control, control Cancer, Cancer-Swim, Cancer-Supplement, Cancer-Saline-Supplement and Cancer-Saline. Swimming and swimming-Supplement groups swam for 6 weeks, five days a week and 60 minutes a day. Supplements and supplements-swimming groups were injected 6 days a day with ginger extract (20 mg / kg) and saline (sodium chloride 0.9%). After intervention, alpha-Tumor necrosis levels (TNFα) and Interleukin10 (IL10) were measured by ELISA and specialized kits. One-way analysis of variance was used to analyze the data (P <0.05).

The results showed that induction of cancer was associated with an increase in TNFα and a decrease in IL10. Six weeks of swimming, supplementation and combined intervention reversed these changes. But there is no significant difference between these three independent variables.

Swimming, supplementation of ginger and their combination may be effective in modulating inflammatory and anti-inflammatory factors in the heart tissue of breast cancer patients.