THE EFFECT OF CHITOSAN-LOADED NANOFIBER DRESSING FOR WOUND HEALING IN MICE MODEL

Wound healing and tissue regeneration are big challenges in medicine. The type of wound dressing has great impact on wound treatment and prevention of superficial infection and scar formation. Wound dressings containing growth factor, antibiotic, antiseptic and antioxidant have great influence in reducing wound scar and accelerating wound healing procedure. Electrospinning is a technique used for the manufacturing of nanofibers with surface nanotopography and density. The spun nanofibers have a three dimensional structure suitable for tissue engineering and wound healing. The aim of this work is to employ electrospinning method for the fabrication of wound dressing containing chitosan for wound treatment and tissue regeneration. Wound dressings were fabricated using the electrospinning method. Physicochemical properties of the dressing were studied using scanning electron microscopy. The efficacies of the wound dress in terms of wound treatment were assessed in excised mice model. Wound dressings containing chitosan nanofibers act as an effective scaffold for skin growth and wound healing. The dressings helped to reduce inflammatory cell count, increase epidermal thickness and improve wound contraction. Chitosan nanofiber wound dressings could be an effective method to enhance wound healing rate