The Effect of Infusion of Intravenous paracetamol on the hemodynamic variables and pain score at post anesthesia care unit after major surgery

Propacetamol (intravenous acetaminophen) is one of the drugs that have recently been considered in the field of pain management. Initial studies that were evaluated the approaches which have identified the cause of the ease of recovery showed that using the multiple analgesic techniques can improve early recovery. Whit regard to the appropriate safety of paracetamol and given the discectomy is a painful operation which require absolute pain relief particularly in postoperative recovery period without complications, we decided to investigately the effects of intravenous acetaminophen on pain score of patients immediately after the operation and the velocity of patients discharge form recovery. In this randomized double-blind clinical trial, 52 patients which candidates for lumbar disc surgery were enrolled. Patients were randomly divided into two groups each included 26 patients. In the first group (A) after the operation 15 mg/kg acetaminophen dissolved in 100 ml of normal saline was infused over 20 minutes. In group (B) patients at the end of operation received only 100 ml of normal saline within 20 minutes. During operation , age ,sex, weight, duration of anesthesia, time of positioning , time of incisions, suture of incision end time, time of return the patient , the number of discs involved, type of surgery, intraoperative complications and recovery time were record. In our study, the mean rate of nausea and vomiting in the control group was 8.8% and 1.15% respectively. The rate of these complications in the intervention group was 10% and 1.9%, respectively that showed no significant difference between the two groups. The statistical analysis in the intervals 25 minutes after arrival in the recovery according to our results suggest that intravenous acetaminophen use the pain relief after surgery as a useful and safe analgesic. Consider the results this study compared whit previous studies we conclude that in patients underwent major surgery, intravenous acetaminophen is an effective drug whit no significant adverse effects that can make a good analgesic effect.