Preparation, Characterization and Analgesic Evaluation of a Novel Physical Hydrogel Composed of Opened-ring poly (Vinyl Pyrrolidone) and Chitosan Containing Ostrich Oil in Mice

Background and

Hydrogels are used as carriers to control drug release. Ostrich oil has fatty acids which plays an important role in growth, division, and health of cells and cause wound healing and have anti-inflammatory effects.

In this experimental study, pH sensitive hydrogel was produced by chitosan deviation and open ring Poly-vinyl pyrrolidon (OR-PVP). The physicochemical characteristics of ostrich oil hydrogel was studied and its analgesic effect on mice was investigated by hot plate and formalin test.

Compared with other formulations, formulations containing chitosan with high molecular weight showed better results. The ratio of OR-PVP to high molecular chitosan was 0.4 for the best formulation. All formulations with 30% ostrich oil were found to have good analgesic effects.

This study showed that ostrich oil hydrogel could reduce inflammation and
central pain