Influence of Sleep Deprivation on the 24-Hour Ghrelin Secretion Pattern
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Blood concentration of many hormones fluctuates during a 24-hour period and sleep deprivation affects this circadian rhythm. The ghrelin hormone is secreted from gastric cells and stimulates hunger. There are a few studies regarding the 24-hour ghrelin secretion pattern in normal subjects, but no studies have addressed the effects of sleep deprivation on this pattern.
Objectives
To assess the 24-hour ghrelin secretion pattern and the effect of sleep deprivation on this pattern.
Methods
This work was conducted on 16 young soldiers (age: 19 - 23 years old) who served in AJA University of Medical Sciences. The participants were divided into two groups. The first group had regular sleep-wake cycle (n = 8). The second group did not have normal arousal cycle (n = 8). Six blood samples were taken from each subject within 24 hours. The samples were centrifuged and serum was frozen to -20°C until the various assays were performed. Serum cortisol and ghrelin levels were measured by the enzyme-linked immunosorbent assay (ELISA).
Results
Cortisol showed a diurnal rhythm with a peak at 06.00 A.M. in the normal and disrupted sleep subjects. However, ghrelin did not show a significant diurnal rhythm in neither group. Sleep deprivation did not have a significant effect on the time pattern of the cortisol and ghrelin secretion.
Conclusions
It seems that in real life, ghrelin does not show a circadian rhythm and sleep deprivation does not impact this rhythm.
Language:
English
Published:
Shiraz Emedical Journal, Volume:19 Issue: 10, Oct 2018
Page:
2
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