The Pregabalin Premedication Effect On Postoperative Pain Management In Mandible Fracture Surgery-Double Blind Clinical Trial

Pain control in mandible surgery has become a challenge for physicians; the effects of using modern methods, such as pre-drugs with oral medicines before surgery, are still in contraversy. Therefore, the aim of this study was to investigate the effects of preglaboline on management of postoperative pain of fracture of the mandible. Material & Methods: In this clinical trial study, after ethical agreement pain management between groups who recived drug (30 patients) and did not receive drug(30 patients) was compared. After random sampling, the intervention group consumed one preglabolin capsule 300 milligrams with 50 ml of water half an hour before surgery. The severity of pain was measured and recorded in both groups during the first eight hours after surgery. Hi square was used to statistical analyzing. Pain severity decreased in both groups over time, but pain was significantly different between two groups (P = 0.001), & hours after surgery, pain severity was 1.76±0.93 and 2.96±1.21 in sample and control groups (P=0.01). Positive effects of pregabalin premedication on better management of pain after Mandibule surgery were observed in this study.