Considering the Zataria multiflora essential oil effect on the xenobiotic metabolism in acute toxicity induced by iron nanoparticle
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Introduction
Considering the importance of iron and the role of oxidative stress in its toxicity, the purpose of this study was to compare the effect of iron nanoparticle and Zataria multiflora essential oils on the activity of biochemical markers of the liver, also activity of CYP450 and GST enzymes was examined in this study.
Materials & Methods
The adult male rats were divided into 5 groups and 3 subgroups, including negative control group receiving normal saline, positive control group receiving 200 mg/kg of iron nanoparticles, and treatment group receiving Zataria multiflora essential oils. The rats received 100 mg/kg b.w, and 200 mg/kg b.w of Zataria multiflora E.O intraperitoneally. Then rats were killed, and their liver tissue was removed for pathologically and biochemically analyze.
Results
In the analysis of AST marker after 72 hours, the injection of iron nanoparticles resulted in an increase in activity of these markers, which shows the hepatocellular injury, and the injection of nanoparticles after 72 hours reduced the activity of CYP450 and GST enzymes. It was found that the treatment of rat animal with Zataria multiflora E.O reactivated the liver marker and GST enzyme. Necrotic foci developed by the damage to iron nanoparticles in hepatocytes were reduced by the treatment with Zataria multiflora E.O.
Conclusion
The use of iron nanoparticles results in damages to the liver tissue and increases in metabolism of xenobiotics, and the treatment with the Zataria multiflora essential oil can prevent and resolve these damages.
Language:
Persian
Published:
Journal of Animan Researches, Volume:31 Issue: 2, 2018
Pages:
172 to 182
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