Comparison of Thermodynamic Modeling of Binary System (Carbon Dioxide-Dimethyl sulfoxide) and Ternary System (Carbon Dioxide-Dimethyl sulfoxide- Ampicillin) via Different Equation of State

The bioavailability and solubility of pharmaceutical compounds are increased via size reduction. One of the new method of size reduction is using of supercritical carbon dioxide. This method has some advantage. The process temperature is not high. Therefore, the nature of pharmaceutical compounds is not damage. The supercritical gas antisolvent (GAS) process not occur at arbitrary operating conditions. Thus, the thermodynamic models are necessary to evaluate the suitable operating condition. In the GAS process, the miscibility of antisolvent and solvent is important factor. In this study, the thermodynamic modeling of binary system carbon dioxide-dimethyl sulfoxide and ternary system carbon dioxide- dimethyl sulfoxide- ampicillin was investigated. The Redlich-Kwong equation of state, the Soave equation of state and the Soave-Redlich-Kwong equation of state was used to model.