Association of adiponectin gene rs2241766 polymorphism with adiponectin levels and lipid profile in patients with non-alcoholic fatty liver

Adiponectin is themostabundant peptide extracted from adipose tissue, which plays an important role in development of obesity. The purpose of this study was to evaluate the association of single-nucleotide polymorphism rs2241766 (+45T>G) with biochemical and anthropometric parameters in patients with non-alcoholic fatty liver. This case-control study was performed on 80 patients with non-alcoholic fatty liver and 80 healthy controls as control (77 men and 83 women). Triglyceride, total cholesterol, HDL and LDL levels were measured by standard methods using Pars Azmoon kit and adiponectin levels with ELISA kit. Genotyping was also performed by PCR-RFLP method. Data were analyzed by SPSS software version 20. Frequency of TG genotype was higher in patients (52.4%) and frequency of TT genotype in healthy people (52.7%), but regression analysis showed that rs2241766 polymorphism genotypes did not play a role in fatty liver disease (p<0.05). The present study showed that none of the variables in the carriers of TT, TG, and GG genotypes was significantly different in the healthy group (p=0/054), but in the patients, the level of cholesterol in the genotypes was significantly different (p<0.05). The results showed that although the frequency of GT genotype and G allele in non-alcoholic fatty liver were more common, there was no significant relationship between rs2241766 polymorphism in adiponectin gene and non-alcoholic fatty liver disease and adiponectin levels