Existential Philosophy of the Immune System: Defense or Homeostasis?

There are two philosophies about the origin of the immune system, defense and homeostasis. In this article, the existential philosophy of the immune system was reviewed, in which the defense role is only part of its homeostasis functions. The Medline was searched for terms such as “Homeostasis” ، “Immunculus” ، “Natural autoantibody” “Evaluation” and “Immune system”.
Findings: Hemostasis is the most important part of immune regulation and the existential philosophy of this system, so that its defensive role is only part of homeostasis functions. Natural antibodies play this role as immune reflection by showing qualitative and quantitative changes in the antigenic composition of the body. Therefore, the level of natural antibodies can also serve as a prognostic marker. Although many improvements have been made in explaining the hemostatic role of the immune system, many studies have to be conducted to identify its particular aspects.