Motor coordination and structural changes of hippocampus tissue in response to eight weeks of aerobic training and Ritalin consumption in hyperactive rats
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Changes in the structure of the hippocampus play a role in the development of attention deficit hyperactivity disorder (ADHD). The aim of this study was to evaluate the motor coordination and structural changes of the hippocampus tissue in response to an 8-week aerobic training program and Ritalin consumption in hyperactive rats.
Materials and Methods
In this experimental study, 33 Wistar rats weighing 180-220g were randomly divided into 5 groups: 1) healthy control, 2) hyperactivity, 3) hyperactivity-aerobic training, 4) hyperactivity- Ritalin, and 5) hyperactivity-aerobic training-Ritalin and respond positively to the open field test. To induce ADHD in the rats, they were injected 10 mg/kg of L-NAME for 8 weeks (6 days per week) based on the weight of the rats. The drug group received 1 mg oral Ritalin per kg weight of rats daily for 8 weeks. The rats performed aerobic training 30 minutes a day and 7 days a week for 8 weeks.
Results
The results showed that aerobic training and Ritalin consumption had no significant effect on weight (P=0.877) but had a significant effect on motor coordination (P=0.001) in hyperactive rats. In rats with the hyperactivity disorder, there was a slight change in the tissue and cellular structure, necrosis and tissue hyperemia as well as piconosis of the hippocampus tissue. Treadmill training along with Ritalin consumption reduced the tissue and cellular damage, necrosis, and also piconosis of the hippocampus tissue.
Conclusion
Attention deficit hyperactivity disorder can cause the structural damage of the hippocampus tissue and treadmill exercises with Ritalin consumption may improve the damage to the hippocampal structureKeywords:
Language:
Persian
Published:
Feyz, Volume:22 Issue: 5, 2018
Pages:
458 to 468
magiran.com/p1908534
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!