GC-MS Analysis of Anti-Candida and Antioxidant Activities of Hydroalcoholic Leaf Extract of Chaerophyllum macropodum
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background

Chaerophyllum is a genus from the family Apiaceae. Chaerophyllum macropodum as a wild species is endemic to Iran and Turkey. The leaves of this plant are used in the food industry, as well as medicine. Since resistance has increased in some Candida species, side effects of chemical drugs and the use of medicinal plants are very important.

Objectives

We reviewed the antioxidant and anti-Candida effects of hydroalcoholic leaf extracts of C. macropodum.

Methods

For the evaluation of the antioxidant potential of C. macropodum extracts, DPPH radical scavenging test, reducing power assay, and β-carotene bleaching test were performed. Moreover, the total free phenolic and flavonoid contents were measured. A GC-MS instrument was used for analyzing the extract components. In addition, hydroalcoholic extraction was performed by agar well-diffusion method against 40 Candida species isolated from patients.

Results

According to the DPPH test, a moderate antiradical activity was attributed to C. macropodum leaf extract; maximum inhibition (6.38) was reported at 1000 μg/mL. Based on the findings, the total phenolic and flavonoid contents were 57.43 ± 0.25 and 138 ± 19.80 (mg/g), respectively. The minimum inhibitory concentrations for C. albicans and C. glabrata were 300 and 400 μg/μL at 48 hours, respectively.

Conclusions

In this study, a moderate antioxidant activity was attributed to C. macropodum leaf extracts. In addition, the results confirmed that leaf extracts had inhibitory activity against bacteria and Candida species. Therefore, they may be applied as antioxidant, antibacterial, and antifungal agents in food protection

Language:
English
Published:
Jundishapur Journal of Natural Pharmaceutical Products, Volume:13 Issue: 4, Nov 2018
Page:
8
magiran.com/p1909029  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!