The relationship between visfatin levels and Anthropometric parameters, and insulin resistance in women with prediabetes and type 2 diabetes

Visfatin is a protein secreted by visceral fat, which plays an important role in the pathogenesis of type 2 diabetes mellitus. Visfatin is also known as Pre-B Cell Colony Enhancing Factor or Nicotinamide Phosphoribosyl Transferase. Visfatin is widely expressed in the visceral adipose tissue and has insulin-like metabolic functions. However, its pathophysiological role in human is still unknown. The aim of this study was to evaluate the relationship between plasma visfatin and obesity, and type 2 diabetes. This case-control study was conducted on 50 women with pre-diabetes and type 2 diabetes, and 50 healthy women. Visfatin and insulin levels were measured using a Mercodia ELISA kit (Mercodia Company, Sweden). The weight, height, waist circumference and FBS were determined using standard methods. Data was analyzed using SPSS software (Version 19). According to the data, plasma visfatin levels increased in patients with prediabetes and type 2 diabetes compared to the control group (p<0/05). There was a meaningful correlation between visfatin and BMI, weight, waist circumference and HOMA-IR (p<0/05). No correlation was found between visfatin and FBS, and insulin in patients with prediabetes and type 2 diabetes. These results suggest that visfatin levels correlate with BMI, weight, and waist circumference, and can be used as a marker for the diagnosis and treatment of type 2 diabetes