Normal hexane occupational exposure estimation in the benchmark response according to color vision impairment
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background and aims

Exposure to the normal hexane can induce dysfunction of the nervous system and color vision impairment. Occupational risk assessment is established according to no observed adverse effect levels (NOAEL). Recently, because of the NOAEL’s limitations, the benchmark responses were applied for risk assessment. The study’s aim is an analysis of benchmark response in occupational exposure to the normal hexane by color vision impairment.

Methods

In this study, inhalation exposure to the normal hexane of some shoemakers was evaluated based on the OSHA ID-07 method. Two samples performed for each subject and cumulative exposure was estimated. Acquired color vision impairment was assessed by a D-15 technique in the both exposed and control groups. A dose-response curve was plotted by normal hexane cumulative exposure and color vision impairment according to the BMDS EPA software.

Results

Exposure to the normal hexane in all studied workers was lower than OELs. It was found that 33% of the exposed groups had acquired color vision impairment. A dose-response curve was evaluated by five exposure groups in the range concentration of 0, 10.82, 11.97, 15.11 and 18.55 mg/m3.The results show Log Logistic model is the best model for the benchmark response prediction. Occupational exposure in 10% of responses (benchmark response) was determined 19.54 mg m-3 with a lower limit of 12.15 mg m-3.

Conclusion

Neurological toxicity occurred in the levels of airborne exposure lower than occupational exposure limit. Accordingly, can be concluded that the new occupational exposure level can be established by further studies and concentrated researches for neurotoxicity of n-hexane through inhalation exposure

Language:
Persian
Published:
Iran Occupational Health, Volume:15 Issue: 4, 2018
Pages:
62 to 72
magiran.com/p1912392  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!