Different levels study of Milk thistle herb and Cotrimoxazole antibiotic on blood metabolites of Ross broilers

Milk thistle plants including medicinal plants useful that its extract has antioxidant and liver protection. The aim of this study was to investigate the effect of different levels of Milk thistle herb and antibiotics Cotrimoxazole on blood metabolites of Ross broilers. In this experiment, milk thistle herb in three levels 0, 0.3 and 3 percent and antibiotics Cotrimoxazole in two levels 0 and 2 kg with 3 repeat were considered. Blood metabolites were measured at 42 days of age. Metabolites include glucose, cholesterol, prothrombin time (PT), uric acid, creatinine and bilirubin. Data to evaluate the effect of factors under study using the general linear model (GLM) and SAS statistical software were analyzed. Antibiotic cotrimoxazole was a significant effect on blood glucose (p<0.05). Milk thistle effect was a significant on blood cholesterol (p<0.05) and Cotrimoxazole antibiotic effect on blood cholesterol was a very significant (p<0.01). Milk thistle effect on uric acid and creatinine levels was a significant (p<0.05). The different levels of Milk thistle was very significant on bilirubin in the blood (p<0.01). Different between mean of Milk thistle and antibiotic cotrimoxazole for prothrombin time (PT) was significant (p<0.05). Use of the Milk thistle levels reduced the liver problems, because the amounts of liver enzymes secreted in the blood was decreased. Level 3% Milk thistle have maximum protective effect on the liver.