Comparison antibacterial activity gelatin nanoparticles and gelatin yellowfin tuna (Thunnus albacares)and determination minimum inhibitory concentration(MIC) and minimum bactericidal concentration(MBC)

With the now diseases and increasing in the antibiotics has been greatly improved to deal with the increasing drug resistance of pathogens. Nanotechnology is a useful way. The aim of this article is to evaluate the gelatin antibacterial property and gelatin nanoparticles against pathogenic bacteria such as E. coli, S. aureus, and P. aueroginosa and were evaluated by calculation of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Gelatin and gelatin nanoparticles were extracted from yellowfin tuna. For antibacterial assay gelatin was disc diffusion and serial dilution methods. For gelatin nanoparticles antibacterial assay was turbidimetric method. Then evaluated antibacterial characters and MIC MBC were determinated. (Comparison gelatin with gelatin nanoparticles antibacterial characters showed that gelatin nanoparticles had antibacterial characteristics against S. aureus, and P. aueroginosa and gelatin had property against P.aueroginosa. Gelatin nanoparticles had lower than MIC and MBC gelatin (P=0/0 24).Gelatin nanoparticles had better antibacterial property than gelatin. The smaller the Gelatin nanoparticles (GNP), the more antibacterial characters (P< 05/0). GNP could be used pharmaceuticals and have antibacterial properties.