The Protective Effect of High Intensity Interval Training Preconditioning on Ischemia Reperfusion-Injury in Ageing Rats

  The heart resistance to ischemia decreases with aging. Exercise training by preconditioning decreases ischemia reperfusion-injury. Therefore the aim of the present study was to investigate the effect of high intensity interval training on ischemia reperfusion-injury in ageing rats.
Material & In this experimental study, 20 ageing male wistar rats (20 months old) were randomly distributed in control (n=10) and training groups (n=10). The training group performed high intensity interval training for 8 weeks. 48 hours after last exercise session, rats were subjected to ischemia via LAD artery ligation for 30 min followed by 90 min reperfusion. After reperfusion, stress oxidative indices and infarction size were measured. To evaluate the difference between groups, independent t-test was used with significant level of p ≤0.05. GPX, Catalase and MDA were not different between two groups, but GSH was more in training rats compared with control groups (p=0.05). Infarction size in response to training decreased by 7% compared with control rats (p=0.001). The results of this study showed that 8 weeks of high intensity interval training probably decrease ischemia reperfusion injury by antioxidant capacity promotion