The effect of vitamin D supplementation on plasma levels of anti-aging protein in elderly
Message:
Abstract:
Background
The percentage of elderly people is growing in our country. Aging is associated with multiple diseases, disabilities and heavy medical expenses. The new multi-functionalProtein, Klotho, not only reduces the aging process but also affects several diseases associated with older ages.The aim of this study was to evaluate the effect of vitamin D supplements on the plasma levels of klotho in the elderly.
Methods
This study was conducted in a randomized clinical trial in 81 elderly, with insufficient vitamin D plasma levels (10-30 ng/ml) for 12 weeks.Individuals randomly divided into two groups of vitamin D supplements (50000 IU) and placebo once a week. Vitamin D was measured by chemiluminescence method and klotho by ELISA. Data was analyzed by SPSS (version 22) software at meaningful level of P <0.05.
Results
25(OH)D levels were increased and decreased significantly in vitamin D and placebo group respectively (p<0.001 & p<0.001 respectively), and its changes between the two groups was significantly different at the end of the intervention (p<0.001). The mean klotho protein levels and its changes after the intervention were significantly different between the two groups (p=0.014 & p<0.001 respectively). The mean klotho protein levels in the vitamin D group was not change significantly (p=0.164).
Conclusion
The findings of this study showed, weekly intake of 50,000 IU vitamin D for 12 weeks in elderly peoplewith insufficient vitamin D levels, caused significant difference in klotho protein and vitamin D changes between the two groups, and also vitamin D levels in vitamin D group was increased significantly at the end of the intervention.
Language:
Persian
Published:
Razi Journal of Medical Sciences, Volume:25 Issue: 9, 2018
Pages:
83 to 92
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