Effect of kind of exercise training on gene expression of β3-ARs and A2ARs receptors of brown adipose tissue in obese male rats

The aim of present study was to investigate the effect of a period of endurance training and high intensity intermittent training on gene expression of β3-Adrenergic (β3-ARs) and A2A (A2ARs) receptors of brown adipose tissue in obese male Wistar rats. In an experimental trial, 15 male Wistar rats were randomly divided into three groups, including endurance training group (n=5), high intensity intermittent training group (n=5) and control group (n=5). The training protocol included 5 sessions per week for 12 weeks. The gene expression of β3-Adrenergic and A2ARs were examined by qRT- PCR. The Kruskal-Wallis was used to analysis the data and significant level was set at p<0.05. There was no significant difference in gene expression of β3-ARs among groups (p=0.097), but endurance training caused the significant increase in gene expression of A2ARs compared to control group (p=0.030). The weight did not show any significant difference among groups (p>0.05). Our results showed that endurance training induced significant enhance in gene expression of A2ARs of brown adipose tissue. This result can be due to suitable intensity and during of this training on A2ARs. According to results of this study, it is concluded that endurance training prevents high fat diet induced obesity.