Effect of High intensity interval training and Crocin on Oxidative Stress in Heart tissue of Male Rats Exposed to Doxorubicin Induction
Background and AimCardiovascular disease is one of the major causes of mortality in the world. Oxidative stress plays a major role in the development and development of cardiovascular diseases. Physical activity improves the antioxidant state of the heart tissue. The purpose of this study was to investigate the levels of oxidative and antioxidant indices of male rats exposed to doxorubicin after eight weeks of high intensity interval training and crocin consumption.
MethodsIn an experimental study, 50 male Wistar rats (average age 8 weeks and weighing 200-200 grams) were randomly assigned into 5 healthy control groups (saline), doxorubicin (control), doxorubicin-crocin, doxorubicin-training, and doxorubicin - training -crocin. The training groups completed the course with two severe alternations in the first week and completed 8 severe alternations in the last weeks. After 8 weeks, the levels of malondialdehyde (MDA), and the activity of superoxide dismutase (SOD) and catalase (CAT) enzymes in the heart tissue were measured. Independent T-test, two way ANOVA were used to analyze the data (p <0.05).
ResultsThe results showed that injection of Doxorubicin with significant increase in malondialdehyde levels and significant reduction of superoxide dismutase and catalase activity were observed in experimental groups. 8 weeks high intensity interval training, crocin and a combination of these two, significantly reversed these changes. It was found that there was no significant difference between the effects of each of the two variables alone, but the combination of training and crocin significantly reduced the level of malondialdehyde index and increased the activity of superoxide dismutase and catalase compared to each of them alone, and these two works reinforced each other.
ConclusionIt seems that high intensity interval training, crocin, or a combination of these two, can reduce the levels of oxidative index, malondialdehyde, and increase the activity of antioxidant enzymes of superoxide dismutase and catalase in the heart tissue, protective effects against Oxidative damage to the heart tissue caused by doxorubicin. It also seems that use of combination of these two interventions is a better preventive and therapeutic strategies compared to each of them application.
Armaghane-danesh, Volume:23 Issue:6, 2019
694 - 708
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