The Effect of High Intensity Interval Training on Retinol Binding Protein 4 and AMP-activated protein kinase Gene Expression in Skeletal Muscle of Rats with Type II diabetes
The positive effects High Intensity Interval Training (HIIT) on reinforcement of healthy muscle tissue metabolism pathways have been proven. One of the goals of diabetes is to degrade glucose metabolism and muscle fat, Therefore, the aim of this study was to investigate the effect of HIIT on Retinol Binding Protein 4 (RBP) and AMP-activated protein kinase (AMPK) gene expression in skeletal muscle of rats with Type II diabetes.
Sixty male Wistar rats (age: 8 weeks, weighing 20 ± 250 g) were randomly divided into 5 groups (n = 12): basal, healthy control, diabetes, HIIT, diabetes and exercise group. Before the start of the training program, all groups except the basal group and control and exercise were injected with nicotinamide-aberbiositosin (STZ) by peritoneal injection of diabetic rats. The training rats were treated for 8 weeks, 5 days a week, with an intensity of 80 to 85% of maximum speed to HIIT exercises. 48 hours after the last training session, after anesthesia, soleus muscle was removed and mRNA RBP4 and mRNA AMPK were measured. Data were analyzed by ANOVA and post hoc Tukey test (P <0.05).
The induction of diabetes caused a significant increase in mRNA RBP4. While the reduction in this gene was significant in the diabetic exercise group and exercise group compared with the diabetes group (p = 0.003). Performing a HIIT exercise significantly increased AMPK mRNA levels compared with the control group for diabetes (p = 0.001). Also, the increase of this gene in the diabetic exercise group and exercise was significantly more than the diabetes group (p = 0.002)
The results of this study showed that the use of HIIT exercise is able to cope with the destructive effects of diabetes by increasing the key factor in the muscle cellular metabolism of AMPK (stimulating the increase of GLUT transfer) and reducing RBP, it can be effective in improving insulin resistance of the muscle cell.
Armaghane-danesh, Volume:23 Issue: 6, 2019
709 - 721  
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