Differentiation and Apoptosis in Mammalian Germ Cellslls

Primordial germ cells (PGCs) are the specialized cells that are created from epiblast cells and after the migration differentiate into spermatogonial cells. Also, Spermatogonial cells differentiate into spermatids during the spermatogenesis process. Created disorders in each of these stages cause infertility, so the recognizing of the mechanism of these cells from the early stages of formation to the differentiation and investigating the effective factors in differentiation can be useful in the treatment of the infertile people. Today, the cultivation of spermatogonial cells and transplantation of these cells can be effective in the investigation of spermatogonial stem cell and the treatment of infertility. In this paper, the formation and migration of primordial germ cells, the spermatogenesis process and the effective factors in differentiation of spermatogonial stem cells are investigated.