Effect of Lactobacillus fermentum on insulin and blood glucose and evaluation of pancreatic tissue changes in alloxan-induced diabetic rats

Probiotics are living microorganisms that have beneficial effects in the body and are used to stimulate the immune system and prevent many diseases in humans and animals. Diabetes is the most common endocrine disorder caused by a relative decrease or a complete lack of insulin, and in the long run it has extensive effects on most tissues in the body. The aim of this study was to evaluate the effect of Lactobacillus fermentum on diabetic rats. For this purpose, 32 rats were selected. The first group: non-diabetic control (n=8), the second group: diabetic control(n=8), the third group: diabetic rats treated with Lactobacillus fermentum (n=8), the fourth group: diabetes rats treated with glibenclamide (n=8). The findings showed that the group receiving Lactobacillus officinalis had a significant decrease (p <0.05) in glucose levels compared to the diabetic control group but, there was no significant increase in serum insulin levels. Also, the tissue sections of the pancreas showed that the bacteria had a recovery effect in the pancreatic tissue. Therefore, the results indicate that this bacterium can be used to reduce the complications and It can be considered in the treatment of diabetes.