The Protective Effect of Royal Jelly on Testicular Histomorphometry and Spermatogenesisin Heat-Stress Exposed Male Rats
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Introduction
Scrotal hyperthermia has been known as a cause of male infertility. Testicular heat-stress even for a single short period can induce destruction in testicular tissue and spermatogenesis disturbances. This study was conducted to determine the protective effects of royal jelly (RJ) against testicular damage and spermatogenesis following heat-stress induction in male rats.
Materials & Methods
In this experimental study, 48 male rats were randomly divided into 8 groups (n=6( including: 1- Control, 2- RJ (100 mg/kg BW/day; PO), 3 , 4 and 5 heat-stressed (43, 39, and 37 for 20 min per day, respectively) and 6, 7 and 8 heat-stressed along with RJ (43, 39, and 37 for 20 min per day, respectively plus RJ at a dose of 100 mg/kg BW/day; PO). Heat-stress was induced through immersion of experimental rat scrotums in a water bath. After 48 days, the animals were sacrificed and left testes were removed and fixed. Five-micrometer testicular tissue sections were prepared and studied using a light microscope.
Findings
The data revealed that diameter and germinal epithelium height of the seminiferous tubules, thickness of basement membrane, number of spermatogenic and Sertoli cells, and testicular weight decreased significantly (p<0.05) in heat-stress groups compared to control and RJ groups. Interestingly, RJ co-administration significantly (p<0.05) ameliorated above-noted parameters in all heat-stress-exposed animals except in 43 heat-stress + RJ group.
Discussion & Conclusions
RJ administration can protect testicular tissue changes and prevent reduction of spermatogenic cell counts in testicular heat stress conditions.Keywords:
Heat Stress , Royal Jelly , Spermatogenesis , Testis , Rat
Language:
Persian
Published:
Ilam University of Medical Science, Volume:26 Issue: 6, 2019
Pages:
69 to 78
magiran.com/p1952724
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!